![The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468 | Journal of Pharmacology and Experimental Therapeutics The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468 | Journal of Pharmacology and Experimental Therapeutics](https://jpet.aspetjournals.org/content/jpet/362/3/489/F1.large.jpg)
The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468 | Journal of Pharmacology and Experimental Therapeutics
![Schematic presentation of the clinical study design for (a) study 1... | Download Scientific Diagram Schematic presentation of the clinical study design for (a) study 1... | Download Scientific Diagram](https://www.researchgate.net/publication/328079447/figure/fig1/AS:960043075772418@1605903514330/Schematic-presentation-of-the-clinical-study-design-for-a-study-1-CYP3A4-victim_Q320.jpg)
Schematic presentation of the clinical study design for (a) study 1... | Download Scientific Diagram
![Clinical pharmacology of the dual orexin receptor antagonist ACT-541468 in elderly subjects: Exploration of pharmacokinetics, pharmacodynamics and tolerability following single-dose morning and repeated-dose evening administration - Clemens Muehlan ... Clinical pharmacology of the dual orexin receptor antagonist ACT-541468 in elderly subjects: Exploration of pharmacokinetics, pharmacodynamics and tolerability following single-dose morning and repeated-dose evening administration - Clemens Muehlan ...](https://journals.sagepub.com/cms/10.1177/0269881119882854/asset/images/large/10.1177_0269881119882854-fig1.jpeg)
Clinical pharmacology of the dual orexin receptor antagonist ACT-541468 in elderly subjects: Exploration of pharmacokinetics, pharmacodynamics and tolerability following single-dose morning and repeated-dose evening administration - Clemens Muehlan ...
![PDF] The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468 | Semantic Scholar PDF] The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468 | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/02e95ca9a69340beca1fbf26930dde6c69df1cc8/57-Figure2-1.png)
PDF] The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468 | Semantic Scholar
![Arithmetic mean (± SD) plasma concentration–time profile of ACT-541468... | Download Scientific Diagram Arithmetic mean (± SD) plasma concentration–time profile of ACT-541468... | Download Scientific Diagram](https://www.researchgate.net/publication/328079447/figure/fig2/AS:960043075764225@1605903514457/Arithmetic-mean-SD-plasma-concentration-time-profile-of-ACT-541468-after.png)
Arithmetic mean (± SD) plasma concentration–time profile of ACT-541468... | Download Scientific Diagram
![Arithmetic mean (± SD) plasma concentration–time profile of ACT-541468... | Download Scientific Diagram Arithmetic mean (± SD) plasma concentration–time profile of ACT-541468... | Download Scientific Diagram](https://www.researchgate.net/publication/328079447/figure/fig4/AS:960043075764231@1605903514713/Arithmetic-mean-SD-plasma-concentration-time-profile-of-ACT-541468-after_Q320.jpg)
Arithmetic mean (± SD) plasma concentration–time profile of ACT-541468... | Download Scientific Diagram
![PDF] The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468 | Semantic Scholar PDF] The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468 | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/02e95ca9a69340beca1fbf26930dde6c69df1cc8/49-Table2-1.png)
PDF] The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468 | Semantic Scholar
![Interaction potential of the dual orexin receptor antagonist ACT-541468 with CYP3A4 and food: results from two interaction studies | SpringerLink Interaction potential of the dual orexin receptor antagonist ACT-541468 with CYP3A4 and food: results from two interaction studies | SpringerLink](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs00228-018-2559-5/MediaObjects/228_2018_2559_Fig4_HTML.png)
Interaction potential of the dual orexin receptor antagonist ACT-541468 with CYP3A4 and food: results from two interaction studies | SpringerLink
![Clinical pharmacology of the dual orexin receptor antagonist ACT-541468 in elderly subjects: Exploration of pharmacokinetics, pharmacodynamics and tolerability following single-dose morning and repeated-dose evening administration - Clemens Muehlan ... Clinical pharmacology of the dual orexin receptor antagonist ACT-541468 in elderly subjects: Exploration of pharmacokinetics, pharmacodynamics and tolerability following single-dose morning and repeated-dose evening administration - Clemens Muehlan ...](https://journals.sagepub.com/cms/10.1177/0269881119882854/asset/images/large/10.1177_0269881119882854-fig4.jpeg)
Clinical pharmacology of the dual orexin receptor antagonist ACT-541468 in elderly subjects: Exploration of pharmacokinetics, pharmacodynamics and tolerability following single-dose morning and repeated-dose evening administration - Clemens Muehlan ...
Study protocol AC-078A201 Multi-center, double-blind, randomized, placebo-controlled, active-reference, parallel-group, polysomn
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Discovery of ORN0829, a potent dual orexin 1/2 receptor antagonist for the treatment of insomnia - ScienceDirect
![The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468 | Journal of Pharmacology and Experimental Therapeutics The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468 | Journal of Pharmacology and Experimental Therapeutics](https://jpet.aspetjournals.org/content/jpet/362/3/489/F5.large.jpg)
The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468 | Journal of Pharmacology and Experimental Therapeutics
![Interaction potential of the dual orexin receptor antagonist ACT-541468 with CYP3A4 and food: results from two interaction studies | SpringerLink Interaction potential of the dual orexin receptor antagonist ACT-541468 with CYP3A4 and food: results from two interaction studies | SpringerLink](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs00228-018-2559-5/MediaObjects/228_2018_2559_Fig3_HTML.png)
Interaction potential of the dual orexin receptor antagonist ACT-541468 with CYP3A4 and food: results from two interaction studies | SpringerLink
Accelerated Development of the Dual Orexin Receptor Antagonist ACTâ•'541468: Integration of a Microtracer in a Firstâ•
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Nonclinical pharmacology of daridorexant: a new dual orexin receptor antagonist for the treatment of insomnia | SpringerLink
![PDF] The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468 | Semantic Scholar PDF] The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468 | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/02e95ca9a69340beca1fbf26930dde6c69df1cc8/61-Figure6-1.png)